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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2163) Last page : ( 2167)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00400.6

The stability of ceftriaxone sodium in vials using different diluents

Haroun Mohammad*

Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, Tishreen University, Latakia, Syria

*Corresponding Author E-mail: mohammad_haroun@yahoo.fr

Online published on 24 August, 2018.

Abstract

Ceftriaxone sodium is an important antibiotic used for intravenous or intramuscular administration. The aim of this study was to evaluate the stability of ceftriaxone sodium in vials that dissolved in different types of diluents when stored in different degrees of temperature and different concentrations. Six diluents were used, lidocaine 1%, lidocaine 2%, dextrose 5%, Nacl 0.9%, mixture serum, sterile water used for injection. The solutions of ceftriaxone sodium in sterile water and dextrose 5% (100mg/ml)showed the most stability for 3 days when stored at 25°C, and for 10 dayswhen stored at 4°C, whereas solutions in lidocaine 2% showed the lowest stability for 8 hours at 25°C, and 8days at 4°C. The concentration of the resulted solution has an important effect on the stability such as, the stability of ceftriaxone sodium in lidocaine 1%with concentration (100mg/ml) showed stability for 9 days when stored at 4°C, whereas for 3 days with concentration (250mg/ml).

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Keywords

Ceftriaxone Sodium, stability, lidocaine 1%, lidocaine 2%, dextrose 5%, Nacl 0.9%, mixture serum, sterile water used for injection.

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