Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 2055) Last page : ( 2057)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00381.5

Effect of lead and aluminium in the levels of dopamine and acetylcholine in the brain male rats

Kadhem Wejdan M., Enaya Hanaa*

College of Education, University of AL-Qadisiyah, Iraq

*Corresponding Author E-mail: hanaaeaya@gmail.com

Online published on 21 August, 2018.

Abstract

The study aims to determine the toxic effects of lead and aluminium in the levels of dopamine and acetylcholine in the brain in male rats. In this experiment (45) animals of male rats were divided randomly into three groups, the first group (C): it as control group was given saline physiological, the second group (G1): that given lead acetate concentration of 60 mg/kg of body weight per dayfor 30 day, the third group (G2): which given aluminium chloride concentration of 70 mg/kg of body weight per dayfor 30 day. The results showed a significant decrease (P<0.05) in the level of dopamine in the brainin each treated groupas compared to the control group. On the other hand, the results showed asignificant increase (P <0.05) in the level of acetylcholine in the brainin each treated groupas compared to the control group.

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Keywords

Aluminium, dopamine, acetylcholine, brain, rats.

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