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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 2040) Last page : ( 2044)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00378.5

Formulation and evaluation of colon specific matrix tablet of metronidazole

Dr. Ajazuddin1,*, Banjare Tripti2, Alexander Amit2, Agrawal Palak2, Bhandarkar Akansha2, Bhatt Aditi2, Gupta Swapnil2, Sahu Hemlata2, Diwedi Shradha Devi2, Sahu Pankaj2, Sahu Siddharth Kumar2, Yadav Pooja2, Sahu Kailash2, Dewangan Deeksha2, Thapa Hemlata2, Deepika2, Soni Sonam2, Sharma Mukesh2, Tripathi D. K.2

1Professor, Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India, 490024

2Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud road, Bhilai, Chhattisgarh, 490024

*Corresponding Author E-mail: write2ajaz@gmail.com, ajazuddin@rungta.ac.in

Online published on 21 August, 2018.

Abstract

Targeting of drug to the colon oral route the drug release is controlled by the gastrointestinal pH, transit times and intestinal flora. Metronidazole is only used antibiotics, which can be used, in colonic disease. Matrix formulations containing various proportions of Xanthan gum and HPMC E5LV were prepared by wet granulation technique using 10% starch paste. Six Matrix tablet formulation (1 to 6) of Metronidazole were prepared different mixture of Xanthan gum and HPMC-E5LV. All the formulations were evaluated for inprocess quality control tests. The in-vitro drug release study first in 0.1N HCl followed by in pH 7.4 phosphate buffer, the formulation F3 show good drug release in control manner. Hence, synthetic polymer such as HPMCE5LV is most cheap and suitable for colonic drug delivery.

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Keywords

Colon targeted delivery, Metronidazole, HPMCE5LV, Xanthan gum, Matrix tablet.

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