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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 1978) Last page : ( 1980)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00367.0

Pyrazolines as potent antioxidant agents

Bhat K. Ishwar1, Kumar Abhishek2,*

1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka

2Assistant Professor, (Department of Pharmaceutical Chemistry) NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore, 575018, Karnataka, India

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 21 August, 2018.

Abstract

A series of novel pyrazoline derivatives have been synthesized known for their wide clinical applications such as antibacterial, anticancer, antifungal and antitubercular agents. Chalcones are known to exhibit interesting pharmacological activities like anti-inflammatory, antileishmanial, antibacterial, antitumor, antimalarial and antitubercular activity. A series of pyrazoline derivatives [Substituted 1, 5-diphenyl-3-(m-tolyl)-4, 5-dihydro-1H-pyrazole] were prepared from chalcones by the reported method, characterized by IR, 1H NMR and mass spectra. The synthesized compounds were evaluated for antioxidant activity studies. Most of the compounds have exhibited promising antioxidant activities.

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Keywords

Chalcones, Pyrazolines, Antioxidant activity.

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