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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 1927) Last page : ( 1929)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00357.8

Pyrimidines as potent antioxidant agents

Bhat K. Ishwar1, Kumar Abhishek2,*

1Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka

2Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore, 575018, Karnataka, India

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 21 August, 2018.

Abstract

A series of novel pyrimidine-2-thiol derivatives (PM1-PM6) have been synthesized upon refluxing 1-(4-nitrophenyl)-3-phenyl substituted prop-2-en-1-one in presence of thiourea and glacial acetic acid. 1-(4nitrophenyl)-3-phenyl substituted prop-2-en-1-one were prepared by condensing 4-nitroacetophenone with substituted benzaldehydes in presence of 20% NaOH as base. The structures of newly synthesized compounds were characterized by IR, 1H NMR and mass spectroscopic studies. Newly synthesized compounds were screened for their antioxidant studies. Most of the compounds exhibited excellent antioxidant activity compared to the standard drug ascorbic acid.

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Keywords

Chalcones, pyrimidine, antioxidant activity.

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