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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 1889) Last page : ( 1893)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00351.7

Studies on bioactive compounds and therapeutic potential of Terminalia chebula seed extract

Mohanasrinivasan V.*, Saranya D, Sumitha V, Kalpana R, Nivetha A

School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu

*Corresponding Author E-mail: v.mohan@vit.ac.in

Online published on 21 August, 2018.

Abstract

The worldwide use of herbal drugs has led to an increase in the demand for medicinal plants. The present work reports on extraction process were done by, Soxhlet apparatus where whole or coarsely powdered crude drug is placed with methanol. Then the extracted aqueous form herbal drugs were screened for antimicrobial activity against various clinical and food borne pathogens (Pseudomonas, Salmonella typhi, Staphylococcus aureus, Klebsiella and E.coli) followed by anti-oxidant, anti-inflammatory and anti-diabetic activity. The present work also reports on characterization and separation of functional group using GC-MS and FT-IR methodology. As a result, the maximum zone of inhibition was found around 0.9mm against Pseudomonas sp. Further, the radicalscavenging activity of the extracts was measured as decolourizing activity followed by the trapping of the unpaired electron of DPPH. The percentage decrease of 1, 1-diphenyl-2-picryl hydrazyl radical (DPPH) standard solution was recorded maximum for 1.5mlwith 14% of activity, followed by anti-diabetic activity with 75% (3ml) and Anti-inflammatory of 175% (3ml). extracts at a concentration of 100 μg/ml.

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Keywords

Soxhlet, Anti-microbial, Anti-Oxidant, Anti-diabetic, Anti-Inflammatory, FT-IR, GC-MS.

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