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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 1768) Last page : ( 1773)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00328.1

Formulation and evaluation of Self-Poring osmotic tablet of diltiazem HCl for the treatment of hypertension

Thapa Hemlata, Alexander Amit, Banjare Tripti, Agrawal Palak, Bhandarkar Akansha, Bhatt Aditi, Gupta Swapnil, Sahu Hemlata, Diwedi Shradha Devi, Sahu Pankaj, Sahu Siddharth Kumar, Yadav Pooja, Sahu Kailash, Dewangan Deeksha, Deepika, Sharma Mukesh, Tripathi D. K., Ajazuddin*

Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024

*Corresponding Author E-mail: write2ajaz@gmail.com, ajazuddin@rungta.ac.in

Online published on 21 August, 2018.

Abstract

With emergence of new technology and concept, self-poring osmotic tablets were developed in order to reduce the complications and problems associated with micro drilling and laser drilling in osmotic tablet. This research describes a very simple and cheap method of developing self-poring osmotic tablet that deliver Diltiazem HCl in a controlled rate for prolonged duration. For this purpose 5 formulations of osmotictablets were prepared through wet granulation technique in which different concentration of sodium lauryl sulphate (SLS) were used as pore forming agent in coating solution. In tablet core also varied concentration of sorbitol as osmogens, guar gum and HPMC were encorporated, which forms gel like matrix through which drug releases at zero order. Through optimization out of 5 formulations, F3 (C2) formulation was selected as best. From result of invitro drug release study it was clear that more concentration of pore former and osmogens releases drug in short time while less concentration takes more time for drug release. Therefore, it is necessary to use SLS, polymer and osmogens in balance concentration for getting optimum control release at zero order upto 24 hrs. Self-poring Osmotic tablets hold promising potential for increasing drug efficacy and reducing dosing frequency with minimal side effects also provides an economic means of developing controlled release dosage forms.

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Keywords

Self-Poring Osmotic Tablet, Diltiazem HCl, SLS, Zero Order, Wet Granulation.

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