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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 2017) Last page : ( 2021)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00374.8

Determination of clopidogrel bisulphate using drug selective membranes

Mansour Oussama1,*, Nashed Dania2, Sakur Amir Alhaj2

1Pharmaceutical Chemistry and Quality Control Dept Faculty of Pharmacy, Al-Andalus University, Syria

2Analytical and Food Chemistry, Dept Faculty of Pharmacy, Aleppo University, Syria

*Corresponding Author E-mail: mansouroussama@yahoo.fr

Online published on 21 August, 2018.

Abstract

Newly developed ion selective electrode has been developed for determination of Clopidogrelbisulphate(CLP) in pure form and pharmaceutical preparations. The selective electrode was constructed from Clopidogrel with pairing agent Nesslerreagentin presence of di-n-butyl phthalate (DBP) as the plasticizing solvent mediator. The electrode displayed a Nernstian response with a mean calibration graphs slopeof 28.37 mv.decade−1, over linear concentration range 10−2-10−5M of the drug, with detection limits 0.063 μMand quantification limits 0.191 μM. The electrode was effective at pH range between 1–3. The influence of possible interfering species such as inorganic cations and pharmacologically related compounds was studied. The electrode showed a fast response of (18±2 sec) for a period of 11 days, without significant change in electrode parameters. The method is precise as shown by mean recoveries range of (97.9–102.9%)with a mean relative standard deviation less than 2.80. The results were compared to those obtained by a reference method. The proposed electrode was used for the determination of CLP in pure form and pharmaceutical formulation.

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Keywords

Ion selective electrodes, Clopidogrel, Nernstian slope, potentiometric determination, Nessler reagent.

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