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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 1729) Last page : ( 1733)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00321.9

Computational study on receptors related to aggressive conduct

Karavadi Balasankar*, Shivashankari S.

Department of Bioinformatics, School of Bio-Chemical Engineering, Sathyabama University, Chennai-600119, India

*Corresponding Author E-mail: balasankar.bioinfo@sathyabamauniversity.ac.in

Online published on 21 August, 2018.

Abstract

Investigations of human behavioral hereditary qualities have made it less demanding to comprehend the relative commitments of hereditary qualities and the environment in watched variety in human conduct The genes responsible for the aggressive conduct with the assistance of literature works on the proteins they code were recognized and the elements of these proteins and the pathways in which they are included are additionally analyzed. As indicated by the elements of these receptors it is watched that over articulation of 2 fundamental receptors prompt strange and expanded aggression. This implies inhibiting over expression would be a source of solution to reduce this abnormal behavior. Along these lines ligands are chosen from Gene Cards and Malacards of their hindering properties which can go about as antipsychotic specialists, dopamine rivals, serotonin rival and antidepressants. These ligands are then screened in view of the ADMET properties. The outcomes demonstrate that ligands, for example, L-tyrosine, dexmethylphenidate, olanzapine, parozetine, selegiline and loxapine are more ideal to tie with the proteins. These ligands are then docked with the receptors to locate the fitting inhibitors. The connection between the receptors and the ligands are examined, the docking study uncovers that the suitable ligands can be utilized as an answer for aggressive, criminal and rough behavioral changes as it holds the ordinary conduct.

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Keywords

Human behavior, Modeling, Docking, ADMET, Ligands.

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