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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1685) Last page : ( 1690)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00314.1

Nanocrystals: A Newer Technological Advancement in Drug Delivery

Xalxo Neha, Naha Anup*, Dhoot Abhishek, Priya Juhi

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka-576104, India

*Corresponding Author E-mail: anup.naha@manipal.edu

Online published on 24 July, 2018.

Abstract

Solubility is defined as dissolution of a solute in a solvent to give a homogenous system. It is an important consideration which is required to achieve appropriate drug concentration in systemic circulation for a chosen pharmacological response. With innovation in technologies, the discoveries of drugs having better efficacy are restricted due to poor solubility, despite having clinical efficacy. Hence it has become a major challenge. More than 50% new chemical entities produced in pharmacy industry are practically insoluble in water. Nano crystals have potential to overcome this issue. They have size in nanometer range (mean diameter < 1000nm) which changes the drug properties dramatically. This review article summaries different methods of preparation, various production technologies available currently in industries; evaluation techniques, applications of nano crystal formulation, future trends and challenges of nano crystal formulation, and various marketed dosage forms developed using nano crystals are discussed.

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Keywords

Nanocrystal, Solubility, Bioavailability, Drug Delivery.

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