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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1671) Last page : ( 1676)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00311.6

Insilico Analysis of non-Structural Protein (NS4b) from DENV-2 Indian Strain for Antiviral Drug Discovery

Upgade Akhilesh1,*, Faldu Nilkanth1, B Kaleeswaran2

1Department of Microbiology, Shree M and N Virani Science College (Autonomous), Rajkot, Gujrat

2Department of Zoology and Biotechnology, AVVM Poondi Pushpam College (Autonomous), Thanjavur, 613503

*Corresponding Author E-mail:

Online published on 24 July, 2018.

Abstract

Dengue viral infection is the second largest threat to life among the viral diseases. The structural and functional analysis of the viral proteins plays important role in drug discovery research. In flaviviruses, series of NS (non-structural proteins) found leads to several functions. NS4B consists of 248 amino acids with 27 kDa molecular mass. It's a hydrophobic amino acid and thought to be present in the membrane. This study aims to predict its epitope binding modes as well as surface accessibility. Homology modeling, model refinement, gene ontology and primary drug screening done using structure based drug designing approach. Various compounds found to be good in binding energy when docked with designated protein cavity. Screened compound has been listed and discussed in details.

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Keywords

DENV, SBDD, RASPD, NS4B, Insilico, dengue.

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