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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1667) Last page : ( 1670)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00310.4

Altered Serum Markers of Omentin and Chemerinin Chronic Renal Failure Patients on Hemodialysis

Sarhat Entedhar Rifaat1,*, Saeed Husamuldeen Salim Mohammed1, Wadi Siham A.2

1Department of Basic Medical Science, Dentistry College, University of Tikrit, Tikrit, Iraq

2Dept. of Pharmacology, Collage of Veterinary Medicine, University of Tikrit, Iraq

*Corresponding Author E-mail:

Online published on 24 July, 2018.

Abstract

Background

Renal disease is a common cause of death and disability in many countries throughout the world. Chronic kidney disease (CKD) is defined as the presence of kidney damage, or a progressive loss of kidney function. Hemodialysis (HD) is implicated to correct the metabolic disturbances as complications have been observed. However; little is known about apelin and chemerin in chronic kidney disease (CKD). Thus, the purpose of this study was to analyseomentin, chemerin, urea (BU), creatinine, globulin, albumin, total protein (TP) serum levels in patients with chronic renal failure (CRF).

Methods

Forty eight patients with CRF on maintenance HD, and another forty eight healthy controls subjects without any clinically detectable diseases have been used as control group were enrolled in the study. The patients were diagnosed by specialist doctors in Kirkuk teaching hospital, Kirkuk, Iraq. The blood samples were collected before and 24–48 hours after hemodialysis sessions. Parameters like omentin, chemerin serum level was assessed by ELISA. Serum BU, creatinine, globulin, albumin, TP levels were measured by spectrophotometric methods before and after hemodialysis session.

Results

Chronic renal failure patients were found to have lower serum chemerin, total protein, globulin, and albumin levels before hemodialysis when compared to healthy control patients and higher levels after hemodialysis when compared to pre-dialysis, while serum BU, Cr, and Omentin-1 levels were found to be higher before hemodialysis compared to control and to increase further after hemodialysis compared to pre dialysis.

Conclusion

Elevated serum omentin and chemerin levels could be considered as an independent predicting marker for progression of CDK.

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Keywords

Chronic renal failure, Hemodialysis, Omentin, Chemerin.

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