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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1640) Last page : ( 1646)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00305.0

Long term toxicity study of a Siddha formulation Kandhaga rasayanam (KR) in Rats

Rajarethinam Meena1,*, Ramaswamy Ramaswamy Selvaratnam2,**

1Research Officer (Siddha), Siddha Central Research Institute, Arumbakkam, Chennai

2Director General, Central Council for Research in Siddha, Arumbakkam, Chennai

*Corresponding Author E-mail: meenaprakashphd@gmail.com


Online published on 24 July, 2018.


Kandhaga rasayanam, a Siddha herbo-mineral formulation is indicated for skin diseases, venereal diseases, urinary tract infections etc. There are 16 ingredients in this formulation. Sulphur is the sole mineral ingredient in this formulation. The objective of this study is to evaluate the long term toxicity of KR in experimental rats. The experimental protocol was approved by the Institution Animal Ethics Committee of National Institute of Siddha. WHO guidelines for traditional medicine was followed to study the long term toxicity. The long term toxicity was conducted for 90 days. Five groups were maintained. There was no mortality throughout the treatment period in both the sexes in all the five groups. No toxic signs were observed. The histopathology results of internal organs did not reveal any abnormality. It is evident from the long term toxicity studies that Kandhaga Rasayanam is non-toxic to experimental animals at the dose of 0.720grams.



long term toxicity, Kandhaga Rasayanam, Siddha, Herbomineral drug.


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