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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1627) Last page : ( 1632)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00303.7

Formulation and Evaluation of Dispersible Tablet of Monteleukast Sodium

Bhatt Aditi, Alexander Amit, Bhandarkar Akansha, Sahu Pankaj, Agrawal Palak, Banjare Tripti, Gupta Swapnil, Sahu Hemlata, Diwedi Shradha Devi, Sahu Siddharth Kumar, Yadav Pooja, Sahu Kailash, Dewangan Deeksha, Thapa Hemlata,  Deepika, Sharma Mukesh, Verma Vinay Sagar, Tripathi D. K.,  Ajazuddin*

Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, 4900024

*Corresponding Author E-mail: write2ajaz@gmail.com, ajazuddin@rungta.ac.in

Online published on 24 July, 2018.

Abstract

Monteleukast sodium is most commonly used in treatment of Asthma. It mainly prevents leukotriene mediated effect associated with asthama. Dispersible tablet are film coated or uncoated tablet that can be dispersed in liquid medium before administration, giving a homogenous dispersion. Dispersible tablet were prepared by using a direct compression method employing super disintegrating agentsuch as cross povidone, cross carmellose sodium and sodium starch glycolate, the tablet were preparedusing various diluents like MCC and lactose. Magnesium stearate and talc is used as a lubricant and glidant. Pre-compression parameter such as angle of repose, bulk density, tapped density, carrs index, hausner ratio carried out to study the flow properties of powder to achieve uniformity of tablet. The prepared tablet were evaluated for hardness, thickness, weight variation friablitity, % drug content, disintegration time and other parameter such as wetting time were also evaluated.

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Keywords

Dispersible tablet, Monteleukast Sodium, Super Disintegrating Agent, Diluents, Pre-Compression Parameter.

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