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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1499) Last page : ( 1504)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00279.2

Methods for Testing Ocular Toxicity: Current Status

Jose Jobin*, Deepthi S, Sandeep D S

Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore-575 018

*Corresponding Author E-mail jobinjose@nitte.edu.in

Online published on 24 July, 2018.


The developed ophthalmic formulations should be tested for ocular toxicity testing like draize eye test. Rapid growth in the field of ocular toxicity testing replaces the usage of animals and to adopt the modified protocols. The researchers have to develop properly validated and regulatory approved options to animal testing. Alternative ocular toxicity testing is based on corneal structure and mechanism through which the specific ocular formulation causes irritation to the eyes. Several alternative assay methods have been introduced in the field of ocular toxicity testing like in vitro organotypic model for testing ocular toxicity and several other methods like Bovine Corneal Opacity and Permeability Assay (BCOP Assay), isolated chicken eye test, isolated rabbit eye test and Hen's egg-test on the chorioallantoic membrane. The ultimate aim of alternate methods of ocular toxicity testing is to develop properly validated and regulatory approved best practices. Hence this review highlights the development in the field of alternative ocular toxicity testing methods.



Draize eye test, in vitro organotypic methods, Three-dimensional corneal epithelial models, ethical issues.


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