[ij] [ij] [ij] 
Email id

Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1429) Last page : ( 1435)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00267.6

Formulation and Characterization of Mouth Dissolving Tablets of Dexamethasone Using Synthetic Superdisintegrants

Ranganathan Venkatalakshmi1,*, Ho Ng Jeng2, Sheshala Ravi3, Chinnappan Sasikala4

1Faculty of Pharmacy, MAHSA University, Jalan SP 2/7, Bandar Saujana Putra, Jenjarom, Selangor, Malaysia-41200

2Multicare Health Pharmacy Sdn Bhd, No 1, Lengkok Puteri Utama, Bandar Puteri, 47100, Puchong, Selangor, Malaysia

3Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam Campus, 42300, Puncak Alam, Kuala, Selangor, Malaysia

4Faculty of Pharmaceutical Sciences, UCSI University, Jalan Menara Gading 1, Taman Connaught, 56000, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia

*Corresponding Author E-mail: lakshmi@mahsa.edu.my

Online published on 24 July, 2018.



Dexamethasone is a synthetic glucocorticoid hormone that is commonly used as antiemetic agent with the combination of Ondansetron. The present research is undertaken to formulate mouth dissolving dexamethasone with different superdisintegrants and to study its drug release profile in human saliva.


Scanning of lambda max and drug-polymer compatibility studies were done for pre formulation studies. Mouth dissolving dexamethasone tablets were formulated using direct compression method with different concentrations of different superdisintegrants. Post compression studies were done after that. The final step of the studies was in-vitro drug release studies.


Lambda max was determined at 239nm. A calibration curve with R2 = 0.9984 was obtained. Dugpolymer compatibility studies showed no interactions between the pure drug sample and the polymers. All formulations have complied with USP specification limit in every physicochemical parameter for a conventional tablet. All formulations released drug completely at the end of 60 minutes.


The formulated mouth dissolving dexamethasone tablets do disintegrate and dissolve rapidly in human saliva. The formulated mouth dissolving tablets showed more rapid drug release as compared to conventional marketed product.



Dexamethasone, mouth dissolving tablets, superdisintegrants, croscarmellose sodium, crospovidone.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
773,920,016 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.