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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 3
First page : ( 829) Last page : ( 835)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00154.3

Insilico Docking Study of the Compounds Identified from the leaves of Orthosiphon stamineus for Hepatoprotective activity

Dr Maheswari C.1,*, Dr Alrohimi Abdul Mohsen2, Dr Tawfik Amany3, Dr Meenashi Vanathi4, Dr Saad Zafer5

1Asst Professor in Pharmacy Practice College of Pharmacy-Female Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia

2College of Pharmacy-Male Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia

3Asst Professor in Pharmacy Practice College of Pharmacy-Male Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia

4 Lecturer, College of Pharmacy-Female Sector Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia

5 Dean, College of Pharmacy, Shaqra University, Al-Dawadmi Kingdom of Saudi Arabia

*Corresponding Author E-mail: maki3kp@gmail.com

Online published on 7 July, 2018.

Abstract

To evaluate the Insilico docking study of the compounds identified from the leaves of Orthosiphon stamieus for Hepatoprotective activity. In the present study, in-silico docking analysis was carried out for the compounds present in leaves of Orthosiphon stamineus in comparison with standard Silymarin against Pregnene X receptor and NF-κb Receptor. Experiments were performed using the program GLIDE (Grid-based Ligand Docking with Energetic) module version 5.9, Schrödinger, LLC, New York, NY, 2013 (Schrodinger Inc.). Compounds 1, 2 and 4 have shown significant Pregnene X receptor inhibitory activity. Of the 3 compounds, compounds 1 and 4 showed maximum Pregnene X receptor inhibition than compound 2 and standard drug Silymarin. Compounds 1, 4 and 7 have shown significant NF-κb Receptor inhibitory activity. Of the 3 compounds, compounds 1 and 4 showed maximum NF-κb Receptor inhibition than the compound 2 and the standard drug Silymarin. The study showed that the leaves of Orthosiphon stamineus is potential for the hepatoprotective activity by inhibiting Pregnene X receptor(PXR) and Nuclear Factor kappalight-chain-enhancer of activated b cells (NF-κb Receptor)

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Keywords

Hepatoprotection, Insilico docking, Orthosiphon stamineus, Pregnene X Receptor, NF-Kb Receptor.

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