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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 2
First page : ( 631) Last page : ( 636)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00118.X

Determination of Prasugrel Hydrochloride in Bulk and Pharmaceutical Formulation Using New Ion Selective Electrodes

Sakur Amir Alhaj1, Nashed Dania1, Haroun Mohammad2,*, Noureldin Imad1

1Analytical and Food Chemistry Dept. Faculty of Pharmacy, Aleppo University, Syria

2Pharmaceutical Chemistry and Quality Control Dept. Faculty of Pharmacy, Al-Andalus University, Syria

*Corresponding Author E-mail: m.haroun@au.edu.sy

Online published on 12 June, 2018.

Abstract

The construction and performance characteristics of Prasugrel hydrochloride (PRS) selective electrodes were developed. Electrodes were based on the incorporation of PRS with pairing agents, Ammonium Molybdate (MOL) and Nessler reagent (NES). The electrodes displayed a Nernstian response with a mean calibration graphs slopes of 59.21, 27.57 mv.decade−1 for the two electrodes respectively, over linear concentration range 10−2-10−5 mol L−1 of the drug, with detection limits 0.063, 0.090 μM and quantification limits 0.27, 0.192 μM for electrode 1 and 2 respectively. The safe pH range of the proposed electrodes was (1–4). The influence of possible interfering species such as inorganic cations and pharmacologically related compounds was studied. The electrodes showed a fast response of (20 ± 2 sec, 17 ± 2 sec) for a period of 11 days, 9 days for electrode 1 and 2 respectively without significant change in electrode parameters. The methods are precise as shown by mean recoveries range of (97.7–102.5%)-(97.3–101%) with a mean relative standard deviation less than 3.14 and 4.46% for electrode 1 and 2 respectively. The results were compared to those obtained by a reference method. The proposed electrodes were used for the determination of PRS in pure form and pharmaceutical formulation.

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Keywords

Ion selective electrodes, Prasugrel, Nernstian slope, potentiometric determination, Ammonium Molybdate, Nessler reagent.

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