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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 2
First page : ( 624) Last page : ( 627)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00116.6

Isolation and Ultra-Purification of Oleic Acid Extracted from Olive Oil Using Urea Crystallization

Aldaw Nisreen1,*, Haroun Mohammad2, Nasser Mohammad1, Mousa Yaser3

1Department of Basic Sciences, Faculty of Pharmacy, Al-Andalus University for Medical Science, Tartous, Syria

2Department of Quality Control and Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Andalus University for Medical Science, Tartous, Syria

3Department of Chemistry, Faculty of Sciences, Tishreen University, Syria

*Corresponding Author E-mail: n.aldaw@au.edu.sy

Online published on 12 June, 2018.


Oleic acid is an omega-9 fatty acid that is found naturally in many vegetable sources and animal products The major component in olive oil is the triglyceride esters of oleic acid. This triglyceride is one of the sources of good cholesterol. Oleic acid USP-NF (United States Pharmacopeia-National Formulary) material is a common pharmaceutical excipient that has been widely used in various dosage forms. In this paper we are describing a method for isolation and purification oleic acid in a high purity 99% from fatty acids extracted from olive oil in coastal region of Syria by selectively using urea addition crystallization and cooling crystallization. A gas chromatography-flame ionization detection (GC-FID) method was used for direct quantitative analysis of oleic acid and related fatty acids in oleic acid USP-NF material.



Oleic acid, Isolation, Urea crystallization.


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