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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5691) Last page : ( 5700)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.01031.4

Formulation, Characterization and Applications on Solid Lipid Nanoparticles-A Review

Reddy S. Harshavardhan, Umashankar M. S.*, Damodharan N.

Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, 603203

*Corresponding Author E-mail: umashankarms269@gmail.com

Online published on 18 May, 2019.

Abstract

Solid Lipid Nanoparticles have emerged as a next generation drug delivery system with potential applications in pharmaceutical field. SLN as colloidal drug carriers incorporating hydrophilic or lipophilic drugs. Proteins and antigens intended for therapeutic purposes may be incorporated or absorbed in SLN. Lipid emerged as very attractive aspirant because of its unique property of enhancing the bioavailability of poorly water soluble drugs solid lipid, one of the physical forms of lipid, is used to formulate nanoparticles, popularly known as SLN, as an alternative carrier system to emulsions, liposomes and polymeric micro and nanoparticles. SLN combine advantages of the traditional systems but avoid some of their major disadvantages. The various routes of SLN administered such as oral, nasal, and pulmonary. SLN comprise a versatile drug delivery system that has been developed for the treatment of a variety of diseases. Present state of the art regarding production techniques for SLN, drug incorporation, loading capacity and drug release, especially focusing on drug release mechanisms. Recently increasing attention has been focused on cosmetics, research, clinical medicine and other allied sciences. These and further administered by parental routes or be alternative routes such as oral, nasal approach to overcome above problem is the packaging of the drug in to particulate carrier system

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Keywords

Nano assembly, Solid Lipid Nanoparticle, Control release, Bioavailability enhancer, Colloidal drug carrier.

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