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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5681) Last page : ( 5686)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.01029.6

Pharmacogenetics and Genetic Polymorphism of CYP Enzymes in Indian Population: A Clinical Review

Rajagopal Shanmuga Sundaram*, Varghese Anila A, Kandasamy Krishnaveni, Sukumaran Bhavatharini

Department of Pharmacology, Department of Pharmacy Practice, J.K.K Nattraja College of Pharmacy, Komarapalayam, Tamilnadu, India

*Corresponding Author E-mail: malshan34@gmail.com

Online published on 18 May, 2019.


Pharmacogenetic polymorphism results from the mutations in a Cytochrome P450 (CYP) gene leading to functional alterations, such as increased or decreased activity and occurs at a frequency of at least one percent in a population. At present clinical situation drug clearance and inter-individual variation in drug response is a usual and complex problem. In this clinical review there is a fast update on pharmacogenetics and genetic polymorphism of CYP enzymes in Indian population.



CYP 450, Pharmacogenetics, Allele, polymorphism.


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