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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5623) Last page : ( 5630)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.01020.X

Determination of Antioxidant and Antidiabetic Activities of Polar Solvent Extracts of Daedaleopsis confragosa (Bolton) J. Schröt

Chandrawanshi Nagendra Kumar*, Tandia Devendra Kumar, Jadhav S. K.

School of Studies in Biotechnology, Pt. Ravishankar Shukla University, Raipur, 492010, India

*Corresponding Author E-mail: chandrawanshi11@gmail.com

Online published on 18 May, 2019.

Abstract

Daedaleopsis confragosa belongs to the family of Polyporaceae, which is a highly variable species, presence maze-like pores, commonly whitish to brownish cap with a zone of color and its pore surface to bruise reddish, which is found in hardwood and stumps. The flesh is very tough nature, not consumed by the human. Although the recent research revealed that it is having the prominent sources of antioxidants and other pharma bio-active component. So, therefore, the present study performed to in vitro evaluation of antioxidant and antidiabetic efficieny. In the present studies, using a various polar solvent for extracts preparation. The experimentations were recorded that the hot water solvent had shown a maximum yield of extracts 50.00 (g/weight of defatted dried mushroom). The significant results were recorded for antioxidant and antidiabetic capacity in different measuring methods. The methanolic extracts (CME) showed the strongest DPPH radical scavenging activity (94.39±0.01), the water extract gave a highest reducing power (84.12±0.00) and maximum hydrogen peroxide inhibitory found for hot water extracts (CHE) (99.32±0.03 at 100 μg/mL. The observed values were expressed in decrease dose-dependently with increasing order of concentration of the extracts with IC50. The studies are suggested that the D. confragosa is having enormous therapeutic and nutritive values, which will be used for various human ailments and also provide alternative sources for the pharmaceutical valued.

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Keywords

Polyporaceae, Antioxidant, Antidiabetic, Polar solvent and Human ailments.

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