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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5439) Last page : ( 5448)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00992.7

Ginger extract protect Iodinated Contrast Media Nephrotoxicity in rats through modulation of Oxidative Stress, Cystain C, NGAL and TNF α

Sherif Mohamed H.1,*, Abas Al-Shimaa M.2, Zaitoun Lobna A.2

1Chemistry Department Faculty of Science, Zagazig University, Egypt

2Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University, Egypt

*Corresponding Author E-mail: dr_shmma@yahoo.com

Online published on 18 May, 2019.



Nephrotoxicity was reported in the initial clinical trials of contrast media.

Aim of study

Our study was designed to evaluate the protective effect of ginger extract against nephrotoxicity induced by contrast agent.

Material and Methods

Animals were divided into 5 groups as follow: Group1 (Control): They were not received any treatment during experiment period. Group2 (Ginger): Animals were deprived from water for 72 hours, then orally administrated with 400 mg/Kg/day of ginger extract for 72 hours. Group3 (protective): Animals were pre administrated orally with ginger extract with 400 mg/Kg for one week, then rats were deprived of water for 72 hours, then urografin was induced by a single (I.V.) at dose of 10mL per kg after that animals were orally administrated with 400 mg/Kg/day of ginger extract for 3 consecutive days. Group 4 (positive)(contrast media): Animals were induced by a single intravenous (I.V.) of urografin at dose of 10mL per kg after deprivation of water for 72 hours. Group 5(therapeutic): Animals rats were deprived of water for 72 hours, then Contrast-induced nephrotoxicity was induced (asgroup 4), after that animals were post administrated with ginger extract 400 mg/Kg (for 3 days).


Administration contrast media caused significant elevation in serum urea, creatinine concentration, kidney tissue levels of MDA and NO. Alsoit caused significant increase in Cystain C, NGAL and TNFα levels. Also it significantly decreased SOD activity and GSH level. Treatment with Ginger extract restored the elevation of concentration of urea and creatinine, also oxidative stress markers in groups 3 and 5 and decreased CystainC, NGAL and TNFα levels. Histopathological analysis confirmed that.


Ginger extract have a protective role in contrast media induced nephrotoxicity.



Nephrotoicity-Diatrizoate-Ginger--Cystain C-NGAL-TNFα.


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