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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5345) Last page : ( 5347)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00973.3

In vitro Anti-Cancer Study of Vitis viniferae, Ixora coccinea and Piper longum Extract on Human Breast Carcinoma Cells

Urolagin Deeparani K.1,*, Jayakumari S.2

1Depatment of Pharmacology, Research Scholar, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai

2Professor and HOD, Depatment of Pharmacolognosy, Vels Institute of Science, Technology and advanced Studies (VISTAS), Pallavaram, Chennai

*Corresponding Author E-mail: deepaurolagin@gmail.com

Online published on 18 May, 2019.

Abstract

Herbal constituents have got some attention because of their chemopreventive action and cost effectiveness to reduce cancer. One of the leading causes of death in women worldwide is breast cancer. The aim of present work is to find out the invitro cytotoxic effect of the constituents of polyherbal extract on MCF-7 human breast cancer cells. Here, we investigated the anti-cancer effects of 3 drug extracts-vitis viniferae-Grape seed (GSE), Ixora coccinea flower and Piper longum root extract against breast cancer treatment. cells was cultured in DMEM supplemented with 10% inactivated Fetal Bovine Serum (FBS), 1% penicillin in an humidified atmosphere of 5% CO2 at 37°C. The IC50 of a drug can be determined by constructing a dose-response curve. The percentage inhibition of vitis viniferae (10–320 μg/ml), Ixora coccinea (10–320 μg/ml) and Piper longum (10–320 μg/ml) treatment of cells resulted in 10–90%, 6–53% and 14–90% growth inhibition respectively. Cell proliferation decreased in a concentration and time-dependent manner. In conclusion, results showed that 3 drug extracts exhibits cytotoxic activity to MCF-7 cells and it could be a potential anticancer drug. Further studies are needed to confirm the mechanism of action of drug extracts.

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Keywords

MCF-7 cells, phenolic compounds, flavonoids, alkaloids, vitis viniferaeIxora coccinea and Piper longum..

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