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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5332) Last page : ( 5336)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00970.8

The Development of Identification and Quantitative Definition Methodic of Active substances of the Ointment “Allergolic”

Olga Rukhmakova*, Tatyana Yarnykh, Olexander Tykhonov

National University of Pharmacy, Valentynovskaya Str. 4, Kharkov, Ukraine, 61168

*Corresponding Author E-mail: drvinraj@gmail.com

Online published on 18 May, 2019.

Abstract

Objectives

To develop identification and quantitative definition methodic of active substances of the ointment “Allergolic”. Materials and Methods: the development of identification and quantitative definition methodic of licorice root dry extract and terbinafine hydrochloride in the experimental series of the ointment “Allergolic” was carried out by HPLC method. To determine the glycyrrhizin acid (GA) used the modification of the procedure described in the State Pharmacopoeia, validation was carried out only for proof of specificity. The method for determining terbinafine hydrochloride has been validated according to the «Specificity» and «Linearity» indices. To confirm the presence of lavender essential oil in the medicine, its identification and quantitative determination using the gas chromatography method was performed in accordance with the requirements of the State Pharmacopoeia. Results and Discussions: based on the conducted research we have developed identification and quantitative definition methodic of active substances of the ointment “Allergolic”, description of which is given in the article. Conclusion: using the HPLC method, an identification was made and the content of GA and terbinafine hydrochloride in the medicine was determined. The content of GA was 13.12 mg, the content of terbinafine hydrochloride-5.07 mg per gram of the ointment. The methodic of identification and quantitative determination of lavender essential oil in the ointment by the gas chromatography method was proposed. Its content ranged from 4.5 mg to 5.75 mg.

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Keywords

Ointment, development, identification, quantitative definition, methodic, active substances.

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