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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5304) Last page : ( 5312)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00966.6

Dynamics Persistent Potential of Bacteria as a Treatment Target in Pyoinflammatory Diseases

Kharaeva Zaira F.1,*, Mustafaev Magomet Sh.2, Blieva Larisa Z.1, Hulaev Ibragim V.3, Gendugova Oksana M.3, Bozieva Djamilya S.3

1Department of Microbiology, Virology and Immunology, Medical Faculty, Federal State Budgetary Educational Institution of Higher Education « Kabardino-Balkarian State University Named after H.M. Berbekov», 173, Chernyshevskogo Str., Nalchick, 360004, Russian Federation

2Department of Surgical Dentistry and Maxillofacial Surgery, Medical Faculty, Federal State Budgetary Educational Institution of Higher Education «Kabardino-Balkarian State University Named after H.M. Berbekov», 173, Chernyshevskogo Str., Nalchick, 360004, Russian Federation

3Department of Pediatric Dentistry, Federal State Budgetary Educational Institution of Higher Education «Kabardino-Balkarian State University Named after H.M. Berbekov», 173, Chernyshevskogo Str., Nalchick, 360004, Russian Federation

*Corresponding Author E-mail: irafe@yandex.ru

Online published on 18 May, 2019.

Abstract

Despite the improvement of methods for bacterial infection treatment, the development of new therapy methods is still relevant. Directed regulatory control of microbe defense mechanisms, based on the principles of molecular biology, is one of the most promising directions of scientific research. Its aim is to investigate the main persistent characteristics of Staphylococcus aureus strains in lacunar tonsillitis and odontogenic phlegmon and to develop methods for suppressing the defensive potential of pathogenic agents. In this study, we used 251 strains of Staphylococcus aureus, which are pathogenic agents of local and generalized infections. Anti-lysozyme, anti-interferon, anti-complement, and catalase activity of bacterial cultures and their ability to resist phagocytosis were investigated. Herbal preparations were studied for the anti-catalase effect. The most effective herbal preparation was verified as part of comprehensive treatment of lacunar tonsillitis and odontogenic phlegmon patients. The clinical implementation of the developed method will significantly reduce the antibiotic pressure, improve the therapy efficacy due to personalized selection of comprehensive treatment, based on the characteristics of the patients’ microflora, which will result a shorter hospitalization periods, help avoid complications, and have significant social and economic effects.

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Keywords

Staphylococcus aureus, Persistence factors, Catalase, Herbal preparations, Lacunar tonsillitis, Odontogenic phlegmon.

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