Cardioprotective Activity of Telmisartan, Metformin and its Combination against Doxorubicin Induced Myocardial Infarction in Rat Model
*Corresponding Author E-mail: email@example.com
The present study was designed to investigate the cardioprotective activity of telmisartan, metformin and its combination against doxorubicin induced myocardial infarction in rat by biochemical analysis.
The therapeutic usefulness of doxorubicin (DXR), an anthracycline antibiotic, is limited by its cardiotoxicity. The study was conducted in albino wister rats (n=24) by using doxorubicin as negative control. the test drug, telmisartan and metformin was given alone and in combination for 15 days orally, on 14th & 15th day doxorubicin(15mg/kg) was injected intraperitoneally after the drug admistration except the normal control group.
The biochemical parameters, Troponin T shown to be negative for drug treated groups and positive for doxorubicin group (negative control). lactate dehydrogenase and CK-MB decreased for drug treated group then the negative control.
These results suggest that the telmisartan and metformin treatment provides a significant cardioprotecive protective effect against acute-doxorubicin induced myocardial infarction in rats.
Telmisartan, Metformin, doxorubicin, cardiotoxicity, cardioprotective effect.