A complete review on Rheumatoid arthritis and Diabetes Mellitus-A Unknown Connection Venkataramanan R. V.1, Sumithra M.2,* 1SRM College of Pharmacy, SRM University, Kattankkulathru, Tamil Nadu, India 2Associate Prof, Department of Pharmacology, SRM College of Pharmacy, SRM University, Kattankkulathru, Tamil Nadu, India *Corresponding Author E-mail: sumi26379@gmail.com
Online published on 30 January, 2019. Abstract Rheumatoid arthritis is chronic, progressive disabling autoimmune disease characterized by systemic inflammation of joints, damaging cartilage and bone around the joint. It is a systemic disease which means that it can affect the whole body and internal organs such as lungs, hearts, and eyes. About 1% of the world's population is affected by rheumatoid arthritis. The rheumatoid arthritis due to primary inflammatory markers such as TNF-α, IL-1, IL-6, and IL-17. Diabetes is the one of important disease which is associated with the Rheumatoid arthritis, condition due to action of inflammatory mediators on insulin and its receptor. There are different animal models are used to induced arthritis in rats to evaluate the anti-arthritis activity of the plants. Review in this article has explored the complete profile of the Rheumatoid arthritis and its mediated diabetes. Top Keywords Rheumatoid arthritis, TNF-α, IL-6, IL-1, IL-17. Top |