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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 11
First page : ( 5166) Last page : ( 5172)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00944.7

Analytical Methods for Determination of Lamivudine and their Applicability in Biological Studies

Nalini C.N.*, Nithya A., Afreen Afnaan, Banu A. Ashraf, Hemalatha P., Gayathri E. J.

C. L. Baid Metha College of Pharmacy, Chennai-97

*Corresponding Author E-mail: nalini_cn@yahoo.co.in

Online published on 30 January, 2019.

Abstract

The drug development plays an important role in maintaining thehuman health. To confirm that the developed pharmaceuticals have the prescribed standards various chemical and instrumental methods were developed. These methods are also useful in reducing the impurities present in the drug moieties developed. Antiretroviral therapy(ART) is the combination of several antiretroviral medicines used to retard the growth rate of HIV in the body. Lamivudine is one of those antiretroviral drugs, that comes under the class of nucleoside reverse transcriptase inhibitors (NRTIs), used primarily in the treatment of AIDS and hepatitis B infection. This review highlights a variety of analytical techniques such as chromatographic, spectroscopic and other techniques; HPLC and HPTLC are most commonly preferred for their high sensitivity and accuracy. By reviewing these latest methods it will become easier for future researchers to make an informed choice. The article focuses on the recently developed and validated methods, both in vivo and in-vitro that are currently used for Lamivudine individually or in combination with other drugs.

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Keywords

Lamivudine, Techniques, Validation, Estimation, HPLC, HPTLC.

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