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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 11
First page : ( 5001) Last page : ( 5007)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00912.5

Comparative Evaluation of Fast Dissolving Tablet of Atorvastatin Calcium using Natural and Synthetic Super Disintegrating Agents

Kumar Girish1,*, Khar R. K.2, Virmani Tarun1, Jogpal Vikash1, Virmani Reshu1

1School of Pharmaceutical Sciences, MVN University, Palwal (Haryana)

2B.S. Anangpuria Institute of Pharmacy, Faridabad (Haryana)

*Corresponding Author E-mail: girish.kumar@mvn.edu.in

Online published on 30 January, 2019.


The aim of this research was to formulate Fast dissolving tablets (FDT) of Atorvastatin calcium using natural super disintegrating agent (Mucilage of plantago ovata) to enhance the patient compliance. The mucilage of Plantago ovata was isolated and characterized by various evaluation parameters like physiochemical tests, pH, viscosity, %LOD, % ash value, swelling index, melting point, particle size and microbial count indicating that results are in accordance with specified limits. The four FDTs (A1-A4) were formulated using mucilage of plantago ovata in 2–11% concentration along with A0 (without superdisintegrating agent) and S1, S2 (synthetic superdisintegrating agents). The tablets were evaluated for flow properties, hardness, friability, weight variation, wetting time, water absorption ratio, disintegrating time, Dissolution profile and ex vivo studies. The results revealed that formulation A3 containing mucilage of Isabgol (Plantago ovate) in concentration of 8% has %DE10min(56.39), T25%(0.87) and 19.11% drug permeation through goat buccal mucosa which was better among all formulations. A3 formulation was compared with conventional marketed tablet revealing that FDTs of Atorvastatin calcium were formulated successfully. The stability studies of A3 were performed and similarity factor (f2) was found 71.08 indicating that A3 is stable after exposure to elevated conditions of temperature and humidity.



Atorvastatin calcium, Fast dissolving tablets, Natural superdisintegrating agents, Isabgol (Plantago ovata) seeds, Ex-vivo studies.


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