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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 11
First page : ( 4974) Last page : ( 4976)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00906.X

Cytotoxicity of 8-Anilino 1-Naphthalene Sulfonic acid and its Degradation Products

Nachiyar C Valli*, Renugadevi K, Sunkar Swetha

Department of Biotechnology, Sathyabama University, Chennai, Tamil Nadu

*Corresponding Author E-mail: vnachiyar@gmail.com

Online published on 30 January, 2019.

Abstract

8-Anilino 1-Naphthalene sulfonic acid is an aromatic amine used extensively in the synthesis of azo dyes. This compound is also produced as an intermediate compound in the bacterial degradation of azo dyes during azo reduction. Moraxella osloensis, a bacterium with dye degrading ability, was checked for its ability to degrade this aromatic amine and the organism was found to be capable of degrading 64% of 20 mg l−1 this amine. The cytotoxicity of this aromatic amine and its degradation products were checked in vitro using HEp2 (human epithelial type 2) and 3T3 (mouse embryonic fibroblast) cell lines. The results indicated the decreased toxicity of the degradation products compared to the aromatic amine. The normal cells were more sensitive to both the aromatic amine and its degradation products compared to the cancer cell lines.

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Keywords

Moraxella osloensis, Anilino Naphthalene Sulfonic acid (ANSA), Biodegradationcytotoxicity.

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