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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 11
First page : ( 4850) Last page : ( 4853)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00882.X

Solubility Enhancement of Itraconazole by Hypromellose Formulated by Solution-Suspension Layering Technique

Kolli Suresh1,*, Sri Vijaya K.2, Murthy P. N.1, Sirisha K.V.R.3

1Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur-760 002, Orissa, India

2Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad-500 014, India

3Asst. General Manager, Ocean Pharma Coat, Jeedimetla, Hyderabad

*Corresponding Author E-mail: kollis.s@gmail.com

Online published on 30 January, 2019.

Abstract

Itraconazole is an imidazole/triazole type, broad spectrum antifungal compound. It has low water solubility and low bioavailablity. In the present study, to enhance the solubility and dissolution rate of Itraconazole, immediate release pellets were formulated by solution-suspension layering using solubility enhancing polymerhypromellose (HPMC). Drug coating was done with Itraconazole and Hypromellose (3 or 5 cps) in different ratios 1: 1.25, 1: 1.5, 1: 1.6, 1: 1.75. A successive seal coat was layered onto the drug pellets with Polyethylene glycol 20000. The prepared pellets were evaluated and compared with marketed formulation for drug content estimation and in-vitro drug release study. Dissolution studies revealed that formulations containing Itraconazole and Hypromellose, 3 cps (1: 1.6), showed better drug release within 45 minutes. The study concluded that the affect of viscosity and concentration of solubility enhancer-Hypromellose on the drug release profile of poorly soluble and low bioavailable drug was ascertained.

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Keywords

Itraconazole, Hypromellose (HPMC), Immediate Release Pellets, Solution-Suspension Layering and in-vitro drug release study.

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