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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 10
First page : ( 4719) Last page : ( 4730)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00861.2

Scaffolds for Biomolecule Delivery and Controlled Release-A Review

Aswin S Keerthic1, Jothishwar S1, Nayagam P Visvavela Chellaih1, Priya G.2

1Department of Biotechnology, School of Bio Sciences and Technology, VIT University, Vellore-632 014, Tamil Nadu, India

2Department of Biosciences, School of Bio Sciences and Technology, VIT University, Vellore-632 014, Tamil Nadu, India

Corresponding Author E-mail:

Online published on 20 December, 2018.

Abstract

A plethora of tissues in our body possess the capability to regenerate barring a few like heart muscles and nerve tissue which cannot regenerate resulting in numerous critical health conditions and diseases (such as cardiovascular, haemato-poietic diseases). Tissue engineering techniques were opted to address this issue by using biomaterials of human origin which closely comprises of physical and chemical properties of a natural tissue to serve as an orchestration for tissue regeneration and wound healing. But it is not an easy task to deliver these biomaterials into the respective tissues. Also, in drug delivery applications, efficacy of both local and systemic administration is not up to the desired level. Hence, Scaffolds which are highly porous structures, allows tissue growth and possesses the potential for the targeted delivery of cells as well as other molecules such as DNA, drugs etc. into the respective tissues. Scaffolds are synthesized from biodegradable material hence they elicit minimal inflammatory and immune response and they can be injected anywhere. They also showcase their ability to take shape of the tissue defect. For all these advantages, scaffolds are considered to be ideal for delivering various molecules for a wide range of purposes. This review is Aimed at presenting the various types of scaffolds which were used for targeted delivery of biomolecules into different tissues for treatment of various diseases, tissue regeneration etc.

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Keywords

Immobilization, encapsulation, electrospinning, fabrication, regeneration.

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