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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 10
First page : ( 4415) Last page : ( 4420)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00808.9

A Concise Study of Metal Impurities as Leachable and Extractable [Lead, Aluminium and Tin] in Eye Drop Formulation and Collapsible Tubes by ICP OES method

Raja M. Gnana1, Dr. Geetha G.2

1KMS Health Center, Chennai, India

2PSG College of Pharmacy, Coimbatore, India

Corresponding Author E-mail: Laconil2002@yahoo.com

Online published on 20 December, 2018.


Metals such as Lead, Aluminium and Tin might some suppliers used in the synthesis of collapsible tube or some trace amount might instantly present in the raw materials of collapsible container. A selective ion determination method was developed by ICP OES for leachable and extractable of metal impurities. The method has been validated by using the parameters RF power of 1.2 KV, plasma flow of 15 L/min, Auxiliary gas flow of 1.5 L/min and plasma view at axial mode for all the metals. The wavelength was monitored for Lead, Aluminium and Tin at 220.353nm, 396.152 and 189.925 nm respectively. The method described is simple, sensitive, rugged, reliable and reproducible for the quantization of Lead, Aluminium and Tin in the leachate and extract from the drug product and container respectively. In this paper completely demonstrated the method of quantification of metal impurities Lead, Aluminium and Tin as a leachate and extract by ICP OES for varies solvents, stress condition and different extraction procedure for marketed eye drops availed in southern part of India.



Leachable and Extractable, Metal impurities, Collapsible Tubes, ICP OES.


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