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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 10
First page : ( 4317) Last page : ( 4323)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00790.4

Synergistic Molecular Effect of BDNF, ApoE and MTHFR in inducing Depression in Alzheimer's Disease

Mir Zainab1, Rosliza2, Naeem Behroz1, Nadeem Ilyas Muhammad2, Prof. Simbak Nordin Bin2, Prof. ALA Zubaidi2, Prof. Ariff Tengku Mohammad3, Khalili M.R4, Kamal Mohammad Amjad5, Baig Atif Amin2,*

1Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, Pakistan

2Faculty of Medicine, Universiti Sultan Zainal Abidin

3iCode-Universiti Sultan Zainal Abidin

4Faculty of Health Sciences, Univeristi Sultan Zainal Abidin

5King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

*Corresponding Author E-mail: atifamin@unisza.edu.my

Online published on 20 December, 2018.


Alzheimer's disease is genetically and pathophysiologically linked to depression. Various studies have been formulated on AD patients with depression and AD patients without depression. Genes like BDNF, ApoE and MTHFR have a significant role in depressed individuals causing the development of Alzheimer's disease. The frequency of each gene marks the onset of Alzheimer's disease. Single Nucleotide Polymorphisms in each specific gene show the increased risks of developing Alzheimer's disease in depressed individuals. Amyloid Senile plaques and neurofibrillary tangles are caused more often in a depressed individual leading to AD. Development of antidepressants may lead to the correction and diminishing of AD in depressed individuals.



Alzheimer's Disease, Depression, BDNF gene, ApoE gene, MTHFR gene, Antidepressants.


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