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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 9
First page : ( 3195) Last page : ( 3204)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00568.6

Alginates: The Wonder Molecule and its Gelling Techniques

Nahar Kamrun1, Md Hossain Kamal1,*, Khan Tanveer Ahmed2

1Vetafarm R & D Center. Vetafarm Pty Ltd, Wagga Wagga, NSW, 2650, Australia

2Faculty of Pharmacy, Al Jouf University, Saudi Arabia

*Corresponding Author E-mail: hossain_238@yahoo.com

Online published on 16 May, 2018.

Abstract

Alginates are quite abundant in nature since they occur both as a structural component in marine brown algae (Phaeophyceae), and as capsular polysaccharides in soil bacteria. Alginates are established among the most versatile biopolymers used in a wide range of applications. Alginate is a biomaterial that has found ample applications in drug delivery due to its favorable properties, including thickening, gel forming, stabilizing and biocompatibility properties. So far more than 200 different grades of alginates are manufactured. The ability of alginate to form two types of gel dependent on pH, i.e., an acid gel and an ionotropic gel, gives the polymer unique properties compared to neutral macromolecules. Alginate is typically used in the form of a hydrogel in biomedicine, including wound healing, drug delivery and tissue engineering applications. The molecule can be tailor-made for a number of applications. This review article gives a comprehensive overview on its physicochemical properties such as manufacturing, chemistry and gelling technology.

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Keywords

Alginate, Ionic gel, Covalent cross link, Thermal gelation, physicochemical properties, Gelling technique.

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