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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 9
First page : ( 2960) Last page : ( 2972)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00525.X

Formulation and Characterization of Efavirenz Nanosuspension by QbD approach

Nawale Rajesh B.1,*, Deokate Uday A.2, Shahi Sadhana R.2, Lokhande Pradeep M.2

1Govt. College of Pharmacy, Osmanpura, Aurangabad-431 005 (M.S)

2Govt. College of Pharmacy, Vidyanagar, Karad, Dist Satara-415 110 (M.S)

*Corresponding Author E-mail: nawale_pharmacy@yahoo.com

Online published on 16 May, 2018.


Poorly water-soluble drugs pose many problems in formulation in conventional dosage forms. One of the critical problems associated with those drugs is low bioavailability and erratic absorption. The problem is even more complex for drugs (belonging to BCS CLASS II) as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2. Nano-suspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages The purpose of this investigation was to reduce the particle size of efavirenz by top down approach i.e. by using high speed homogenizer. The main objective of the study is to prepare nano-suspension of efavirenz by applying design expert and evaluation of nano-suspension.



Nano-suspension (NS), Efavirenz (EFV), QbD, Factorial design, High speed homogenizer.


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