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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 9
First page : ( 2867) Last page : ( 2870)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00505.4

The Impact of IL-10 C-597A Gene Polymorphisms on Asthma Susceptibility

Gaidan Ayad M.1, Abbas Ahmed A.2, Hassan Mohammed A.3, Hashim Hashem M.4, Al-Mayah Qasim S.5

1College of Medicine, Al-Nahrain University

2Department of Microbiology, College of Medicine, Al-Nahrain University

3Microbiology-Department of Microbiology, College of Medicine, Baghdad University

4Department of Internal Medicine. College of Medicine, Al-Nahrain University

5Medical Research Unit-College of Medicine, Al-Nahrain University

Corresponding Author E-mail: sciencefond2015@gmail.com

Online published on 16 May, 2018.

Abstract

Asthma is a chronic disease with multiple environmental and genetic causes. Genetically, gene encoding for some interleukins are particularly important in asthma. Single nucleotide polymorphisms in the promoter regions of these genes may affect the quantity or even quality of the encoded protein and eventually the occurrence of asthma. This study aimed to assess the impact of IL-10 C-597A single nucleotide polymorphism on the incidence of asthma. A total of 45 patients with asthma were enrolled in this study. Other age-and sex-matched 40 apparently healthy subjects were recruited to represent the control group. Three mL of venous blood were obtained from each subject from which DNA was extracted and IL-10 C-597A gene was simplified with specific primers. Genotyping was achieved by direct sequencing. The heterozygote genotypes IL-10 C-597A (CA) showed significant association with asthma (OR = 12.667, 95% CI= 2.71–59.198, P= 0.001). The only demographic factor which had significant association with asthma is family history (P<0.001). The results of this study strongly suggest the significant role of allele A of the IL-10 C-597A as a risk factor for asthma.

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Keywords

Asthma, IL-10 C-597A, Single nucleotide polymorphism.

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