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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 8
First page : ( 2693) Last page : ( 2696)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00478.4

Diagnostic Value of magnetic resonance spectroscopy in Morphometrical Analysis of basal ganglia in patients with Idiopathic Generalized Epilepsy

Dayani Mohammad Ali1, Daneshi Abdolhadi2, Ahadi Reza3, Shekarchi Babak4, Fatehi Daryoush5,*

1Department of Radiology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

2Department of Emergency Medicine, Shohadye Haftom Tir Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Neuroscience, Faculty of Medicine, Iran University of Medical Sciences, Hazrat Rasool Hospital, Tehran, Iran

4Department of Radiology, 501 Hospital, AJA University of Medical Sciences, Tehran, Iran

5Department of Medical Physics, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran

*Corresponding Author E-mail: d.fatehi@gmail.com

Online published on 26 March, 2018.



Idiopathic generalized epilepsy (IGE) is a kind of epilepsy that has tonic-colonic characteristic and myocolonic tensions and its clinical symptom starts from the first 20 years of the life. Proton magnetic resonance spectroscopy (H1-MRS) technique applies as a noninvasive procedure to find metabolic disorders by evaluating brain metabolites. Purpose of this study was metabolical and morphological analysis of the thalamus using MRS imaging in patients with IGE.

Materials and Methods

Applying H1-MRS (technique: PRESS-CSI), we evaluated thalamus images of 63 people (35 controls: 23 males, 12 females, ranging in age 19–46 years, average: 34.8±0.62 years) and 28 IGE patients (10 males, 18 females, ranging in age 20–49 years, average: 37.4±1.04 years). The data analyzed by SPSS (v.20).


Comparing the average NAA/Cr for the right thalamus, a significant reduction was seen between the control group and the IGE patients (p<0.0001). Likewise, for the left thalamus, the NAA/Cr was significantly decreased when we compared it for the control group and the IGE patients (p<0.001).


H1-MRS could be a suitable diagnostic technique to evaluate epilepsy in IGE patients. The possible alteration of neuronal pathways in the thalamo-cortical circuit seems to play a critical role in epileptogenesis of IGE.



Morphometry, Idiopathic epilepsy, thalamus, magnetic resonance spectroscopy.


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