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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 8
First page : ( 2587) Last page : ( 2590)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00459.0

A Prospective Observational Study on Depression in Epileptic Patients

Mammen Keziya Ann, Kumar S. Sathesh*

School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Pallavaram, Chennai-600117, India

*Corresponding Author E-mail: sathesh2000@gmail.com

Online published on 26 March, 2018.



To assess the incidence of depression in patients with epilepsy and also to assess their health related quality of life (HRQOL).


A prospective observational study was conducted in a multi-specialty hospital, from October 1st 2016-march 1st 2017. Adults diagnosed with epilepsy who were on AED's for at least 3 months were included in the study with informed consent. Rate of depression was determined using the Hamilton Rating Scale for Depression (HAM-D). Quality Of Life in epilepsy patient was evaluated using patient weighted quality of life-10 (QOLIE-10 P) questionnaire.


A total of 59 patients were included in the study where 54% were male (n=32) and 46% were female (n=27). Mean age of the patients was obtained as 42.6 ± 3.25 (Mean±SD). Moderate depression was found to be prevailing more among the study population (n=20, 33.89%) and it was found mostly in males (n=12, 20.33%) than compared to females. There is no significant difference (P<0.05) based on analysis of seizure type in patients with or without depression. QOLIE-10 P scores were low with a mean of 23.41± 12.47. Most of the epileptic patients presented with a low QOL score (n=26, 44%) which implies lower quality of life.


This study demonstrates that depression has a significant impact on the quality of life in epileptic patients. Therefore, proper management for depression should be provided in order to improve the health related quality of life (HRQOL) in epileptic patients.



Epilepsy, Health Related quality of life, depression, seizure, anti-epileptic drugs.


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