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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 7
First page : ( 2194) Last page : ( 2202)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00387.0

Comparative study of mode of addition of super Disintegrants on Methocarbamol tablets by Roller Compaction method

Latha S. Madhavi1,*, Babu J. Ramesh2

1Department of Pharmaceutics, Aditya Pharmacy College, Aditya Nagar, ADB Road, Surampalem-533437, East Godavari District.

2Department of Pharmaceutics, CHIPS, Chowdavaram, Guntur.

*Corresponding Author E-mail: madhavilatha61@gmail.com

Online published on 17 October, 2017.

Abstract

Methocarbamol, a BCS class II drug is an antispasmodic agent used to treat the spasms from peripheral musculoskeletal conditions. The research focus in recent years has shifted to the formulation of both fast dissolving and disintegrating tablets that are swallowed and tablets that are intended to dissolving in the oral cavity. Super-disintegrants are now frequently used in tablet formulation to improve the rate and extent of tablet disintegration and thus improve the rate of drug dissolution. The majority of this research has been directed at the function-related properties of the super-disintegrants with special emphasis on correlating these properties to disintegrant efficiency and drug release. The present study was to formulate immediate release tablets using various types of disintegrants in order to investigate the effect of mode of incorporation of disintegrants on release of drug from tablets. Methocarbamol immediate release tablets were prepared by the roller compaction method by using a plasdone S630 as binder and four different disintegrants in combination of three modes of incorporation. The prepared tablets were characterized based upon their physicochemical characteristics. The results showed that F4 (CCS) and F7 (PP-XL) 3% formulations exhibit faster release when compared to others. It may be concluded that intra-granular addition has given improved drug release from dosage form when compared to extra-granular and both intra and extra-granular addition.

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Keywords

Methocarbamol, Roller compaction method, Super-disintegrants, intra-granular mode of addition.

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