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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 7
First page : ( 2189) Last page : ( 2193)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00386.9

Docking Studies of Piperine-Vitamin a Conjugate to Study the Increase in Bioavailability of Vitamin A

Mokkapati Animisha1, Nagumantri Radha Krishna1, Pydi Chinna Babu1, Chintala Ramakrishna2, Rentala Satyanarayana1,*

1Department of Biotechnology, Institute of Technology, GITAM University, Gandhi Nagar, Visakhapatnam, 530 045, India

2GITAM Institute of Science, GITAM University, Gandhi Nagar, Visakhapatnam, 530 045, India

*Corresponding author e-mail: dr.satya@gmail.com

Online published on 17 October, 2017.


Piperine, a major constituent of Piper nigrum (Black pepper), is one of the well known components in many Ayurvedic formulations. Piperine is most studied bioenhancer because it inhibits drug metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprotein substrates. However, there are no evidences on piperine-vitamin A conjugate to inhibit human CYP450 3A4. In this paper the influence of piperine-vitamin A conjugate to study the metabolism of vitamin A with CYP450 3A4 was investigated. In silico results showed in the present study when piperine was conjugated with vitamin A, CYP450 3A4 was inhibited. This method improved the binding of piperine-vitamin A conjugate with CYP450 3A4 and increased bioavailability of Vitamin A.



Bioenhancer, Drug absorption, Cytochrome P450 isoenzymes, Piperine-vitamin A conjugate and docking scores.


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