[ij] [ij] [ij] 
Email id

Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 6
First page : ( 1881) Last page : ( 1885)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00330.4

Asymmetric synthesis of chiral alcohols for API production using microorganisms-A mini review

Saravanan J.1, Suneetha V.2,*

1Anthem Biosciences Private Limited, Bangalore.

2School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India

*Corresponding Author E-mail: vsuneetha@vit.ac.in

Online published on 22 September, 2017.


Biotransformation of chiral intermediates using micro-organism has widely used in many industries due to green technology and cost effectiveness. Moreover, Enzymes are highly ‘Chemo, regio, and enantio selective’ in nature. From decades, bio-reduction performed using whole cells and free enzymes for the production of chiral alcohols. Some recent developments in the area of fermentative biotransformation processes for the reduction of Keto- sulfone to hydroxy sulfone and Lipitor intermediate are reviewed and importance of microbial mediated asymmetric synthesis of chiral alcohols are highlighted for the future perspective.



Asymmetric keto-reduction, Fermentation, chiralalcohols, Hydroxy sulfone, Lipitor, Microorganisms, Keto-reductases.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
760,995,735 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.