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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 6
First page : ( 1881) Last page : ( 1885)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00330.4

Asymmetric synthesis of chiral alcohols for API production using microorganisms-A mini review

Saravanan J.1, Suneetha V.2,*

1Anthem Biosciences Private Limited, Bangalore.

2School of Biosciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India

*Corresponding Author E-mail: vsuneetha@vit.ac.in

Online published on 22 September, 2017.

Abstract

Biotransformation of chiral intermediates using micro-organism has widely used in many industries due to green technology and cost effectiveness. Moreover, Enzymes are highly ‘Chemo, regio, and enantio selective’ in nature. From decades, bio-reduction performed using whole cells and free enzymes for the production of chiral alcohols. Some recent developments in the area of fermentative biotransformation processes for the reduction of Keto- sulfone to hydroxy sulfone and Lipitor intermediate are reviewed and importance of microbial mediated asymmetric synthesis of chiral alcohols are highlighted for the future perspective.

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Keywords

Asymmetric keto-reduction, Fermentation, chiralalcohols, Hydroxy sulfone, Lipitor, Microorganisms, Keto-reductases.

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