Synthesis and biological evaluation of novel imidazolinone derivatives Revanasiddappa B. C.*, Kumar M. Vijay, Nayak Prashanth, Ali Ajmal Roshan, Kalsi Jasmine Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India *Corresponding Author E-mail: evergreen_revan@rediffmail.com
Online published on 22 September, 2017. Abstract A new series of Oxazolones (2a-j) were prepared by reacting substituted aromatic aldehydes with N-acetylglycine in presence of anhydrous sodium acetate and acetic anhydride as the solvent medium. The respective Oxazolones (2a-j) were then treated with 4-Amino-1,2,4-triazole (1) in glacial acetic acid medium to yield the title compounds Imidazolinones (3a-j). All the newly synthesized compounds were evaluated for their In -Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of 1H-NMR, IR, Mass spectral data and elemental analysis. Top Keywords Oxazolones, Imidazolinones, N-acetylglycine, Antibacterial, Antifungal. Top |