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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 6
First page : ( 1726) Last page : ( 1729)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00304.3

Synthesis and biological evaluation of novel imidazolinone derivatives

Revanasiddappa B. C.*, Kumar M. Vijay, Nayak Prashanth, Ali Ajmal Roshan, Kalsi Jasmine

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India

*Corresponding Author E-mail: evergreen_revan@rediffmail.com

Online published on 22 September, 2017.


A new series of Oxazolones (2a-j) were prepared by reacting substituted aromatic aldehydes with N-acetylglycine in presence of anhydrous sodium acetate and acetic anhydride as the solvent medium. The respective Oxazolones (2a-j) were then treated with 4-Amino-1,2,4-triazole (1) in glacial acetic acid medium to yield the title compounds Imidazolinones (3a-j). All the newly synthesized compounds were evaluated for their In -Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of 1H-NMR, IR, Mass spectral data and elemental analysis.



Oxazolones, Imidazolinones, N-acetylglycine, Antibacterial, Antifungal.


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