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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 5
First page : ( 1481) Last page : ( 1484)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00261.X

Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives

Revanasiddappa B. C.*, Kumar M. Vijay, Nayak Prashanth, Ali Ajmal Roshan, Jisha M. S.

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India

*Corresponding Author E-mail: evergreen_revan@rediffmail.com

Online published on 17 July, 2017.

Abstract

A novel series of Chalcones (2a-j) were prepared by reacting Furfuraldehyde and substituted ketones in alcohol medium in presence of NaOH. The Chalcones undergoes selective cyclization with Benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted Pyrazolines (3a-j). All the newly synthesized compounds were evaluated for their In-Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of 1H-NMR, IR, Mass spectral data and elemental analysis. Some of the tested compounds showed potent activity against antifungal organism A.fumigatus.

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Keywords

Pyrazolines, Chalcones, Furfuraldehyde, Benzhydrazide, Antibacterial.

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