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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 5
First page : ( 1426) Last page : ( 1428)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00252.9

Synthesis and Antimicrobial Evaluation of Different Substituted Phenylpropenone Pyrrolyl Chalcones

Kumar Pankaj, Kumar Abhishek*, S Deeksha, G Nireeksha, D'Souza Shalet

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 17 July, 2017.

Abstract

The appearance to antimicrobial resistance to the antimicrobial agent has become a matter of high concern for health care professionals since last ten years. It will an effort to establish new phenylpropenone pyrrolyl; chalcones as improved antimicrobial agent. In this particular series of novel substituted phenylpropenone pyrrol (AP1-AP5) were synthesized by simple condensation reaction between different substituted aldehydes and 3 acetyl-2, 4-dimethyl pyrrole in presence of a strong ethanolic base to yield the chalcones. The structures of the final synthesized compounds were characterized by IR, mass and 1H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosaby cup plate method. Most of the compounds exhibited promising antibacterial activity

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Keywords

3 Acetyl-2,4-dimethyl pyrrole, phenylpropenone pyrrol, Antibacterial, INTRODUCTION.

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