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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 5
First page : ( 1333) Last page : ( 1338)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00236.0

Pedalium murex Linn leaves against LPS-induced oxidative stress, anxiety and depression behavioural alterations in rats

Gomathi S.1,*, Sundaram R. Shanmuga2, Vijayabaskaran M.1, Kannan C.3, Sambathkumar R.3

1Department of Pharmaceutical Chemistry, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu-638183

2Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu-638183

3Department of Pharmaceutics, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu-638183

*Corresponding Author E-mail: gomathiswaminathan03@gmail.com

Online published on 17 July, 2017.

Abstract

Background

Studies of antioxidant substances in foods and natural products have gained increasing interest. The prevalence of neurodegenerative diseases are increasing globally. Effective treatment is necessary to minimize the neuronal damage and oxidative stress. Traditional medicines offer potent pharmacological activity with minimal side effects compared to synthetic drugs to treat such chronic disorders.

Objective

The present study was aimed to evaluate the neuroprotective effect of ethanol extract of Pedalium murex Linn. (EEPM) leaves against lipopolysaccharide (LPS)-induced endotoxemia.

Materials and Methods

Neurodegeneration was induced in rats with a single intraperitoneal injection of LPS (1 mg/kg). The neuroprotective activity was investigated following LPS-induced endotoxemia and then subjecting the animals to a battery of behavioural tests such as open field test (OFT), elevated plus-maze (EPM) and forced swim test (FST) to test anxiety and depression. At the end of the study, rats were sacrificed, brain hippocampal region was isolated and biochemical parameters were analysed.

Results

These results highlight the neuroprotective potential of EEPM in LPSinduced anxiety and depressive illness model which may be partially due to inhibition of oxidative stressneuroinflammatory cascade.

Conclusion

The present study proved that EEPM has promising anti-anxiety, antidepressant action and can be potential candidates for the management of LPS-induced neurodegeneration.

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Keywords

Anxiety, depression, lipopolysaccharide, oxidative stress, neuroprotection.

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