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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 1155) Last page : ( 1159)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00208.6

Synthesis and Physico Chemical Studies of Some Chalcone and Their Derivatives as Potential Antimicrobial Agents.

Kumar Arun1, Gupta Vinita2, Singh Sanchita2, Gupta Y.K.3,*

1Research Scholar, School of Applied Sciences Singhania University Pacheri Bari, Jhunjhunu (Raj.), India

2Department of Chemistry, Agra College, Agra, U.P, India

3Head Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, India

*Corresponding Author E-mail: ykgbkbiet123@gmail.com

Online published on 17 July, 2017.

Abstract

The Chalcone is an aromatic compound that forms the central core for various necessities of biological compounds. The Chalcone is synthesized by Claisen-Schmidt condensation of benzaldehyde derivatives with acetophenone derivatives in dilute ethanolic sodium hydroxide solution at room temperature. The structures of synthesized compounds were investigated by IR Spectroscopy, NMR Spectroscopy and Mass Spectrometry. The antimicrobial activity of the synthesized was evaluated by Filter Paper Disc diffusion Method. The compound 1b showed excellent activity against S. aureus at both concentration i.e. 500μg/ml and1000 μg/ml.

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Keywords

Chalcone derivates, Antimicrobial agents.

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