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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 4
First page : ( 1145) Last page : ( 1148)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00206.2

First order derivative spectrophotometric methods for the determination of Fluorometholone in ophthalmic preparations

Teja Bulusu Ravi, Varma Bhupathi Raju Kishan, Kumar Chandaka Prasanna, Annapurna Mukthinuthalapati Mathrusri*

Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, India

*Corresponding Author E-mail: mathrusri2000@yahoo.com

Online published on 17 July, 2017.


Three simple spectrophotometric techniques have been developed for the quantification of Fluorometholone in ophthalmic preparations using sodium acetate buffer (pH 4), phosphate buffer (pH 4) and phosphate buffer (pH 7) solutions. Linearity was observed over the concentration range 2–25, 2–30 and 1–50 μg/mL in sodium acetate buffer, phosphate buffer (pH 4) and phosphate buffer (pH 7) respectively. The three methods were validated and can be applied for the assay of Fluorometholone in pharmaceutical formulations.



First order derivative spectrophotometry, Fluorometholone, Validation.


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