Formulation and In-Vitro Evaluation of FDC Bilayer Matrix Tablets Containing Telmisartan as Sustained Release and Hydrochlorothiazide as Immediate Release Khan Hamid1,*, Ali Mushir2, Ahuja Alka2, Ali Javed2 1Associate Professor, JK College of Pharmacy, Bilaspur, Chhattisgarh India-495001 2Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India-110062 *Corresponding Author E-mail: khanhamid770@gmail.com
Online published on 17 July, 2017. Abstract The aim of the presented work was formulation and in-vitro evaluation of bilayer tablets containing telmisartan as sustained release (SR) and hydrochlorothiazide as immediate release (IR) using HPMC. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min. Top Keywords Bilayer tablet, telmisartan, hydrochlorothiazide, sustained release, immediate release. Top |